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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine (Code C103830)

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Terms & Properties

Preferred Name: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine

Definition: A recombinant chaperone-peptide complex-based vaccine composed of a complex between heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential antineoplastic activity. Upon vaccination, recombinant hsp110-gp100 chaperone complex activates the immune system to exert a cytotoxic T cell immune response and antigen-specific interferon-gamma production against gp100-overexpressing cancer cells. Gp100, is overexpressed in a variety of cancer cell types. Hsp110, binds to and chaperones full-length proteins during heat shock; as an immunoadjuvant it is able to enhance an immune response against antigen(s) and stimulate T-lymphocyte activation.

Display Name: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine

Label: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine

NCI Thesaurus Code: C103830 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438310  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 742760
PDQ Open Trial Search ID 742760 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438310

Other Properties:
     Name Value (qualifiers indented underneath)
code C103830
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103830

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