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Version: 17.06d (Release date: 2017-06-26)
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FAP-specific CD8-positive T Cells (Code C103829)

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Terms & Properties

Preferred Name: FAP-specific CD8-positive T Cells

Definition: A preparation of CD8-positive T cells specific for human fibroblast activating protein (FAP) with potential immunopotentiating activity. T cells have been genetically modified to express a chimeric antigen receptor specific for FAP. Upon infusion, the FAP-specific CD8-positive T cells bind to FAP-expressing tumor cells and exhibit a selective toxicity to tumor cells. This may result in both tumor cell lysis and inhibition of tumor cell growth. FAP, a cell surface glycoprotein, is overexpressed on tumor-associated fibroblasts but minimally expressed on normal, healthy cells.

Label: FAP-specific CD8-positive T Cells

NCI Thesaurus Code: C103829 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438309  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FAP-specific CD8-positive T Cells

External Source Codes: 
PDQ Closed Trial Search ID 742755
PDQ Open Trial Search ID 742755 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438309

Other Properties:
     Name Value (qualifiers indented underneath)
code C103829
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103829

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