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Version: 17.06d (Release date: 2017-06-26)
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Galectin-1 Inhibitor OTX008 (Code C103828)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Galectin-1 Inhibitor OTX008

Definition: A calixarene-based compound and galectin-1 (Gal-1) inhibitor with potential anti-angiogenic and antineoplastic activities. Upon subcutaneous administration, galectin-1 inhibitor OTX008 binds Gal-1 which leads to Gal-1 oxidation and proteosomal degradation, through an as of yet not fully elucidated mechanism, and eventually downregulation of Gal-1. This decreases tumor cell growth and inhibits angiogenesis. Gal-1, a multifunctional carbohydrate-binding protein, is often overexpressed on tumor cells and plays a key role in cancer cell proliferation, apoptosis, tumor angiogenesis and evasion of immune responses.

Label: Galectin-1 Inhibitor OTX008

NCI Thesaurus Code: C103828 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3641630  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gal-1 Inhibitor OTX008
Galectin-1 Inhibitor OTX008
OTX008

External Source Codes: 
PDQ Closed Trial Search ID 742751
PDQ Open Trial Search ID 742751 (check for NCI PDQ open clinical trial info)
UMLS CUI C3641630

Other Properties:
     Name Value (qualifiers indented underneath)
code C103828
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103828

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