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Version: 17.06d (Release date: 2017-06-26)
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Taladegib (Code C103826)

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Terms & Properties

Preferred Name: Taladegib

Definition: An orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

Display Name: Taladegib

Label: Taladegib

NCI Thesaurus Code: C103826 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3641628  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide
Benzamide, 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)-
LY-2940680
LY2940680
Taladegib
TALADEGIB

External Source Codes: 
CAS Registry Number 1258861-20-9 (see NLM ChemIDplus info)
FDA UNII Code QY8BWX1LJ5
PDQ Closed Trial Search ID 688313
PDQ Open Trial Search ID 688313 (check for NCI PDQ open clinical trial info)
UMLS CUI C3641628

Other Properties:
     Name Value (qualifiers indented underneath)
code C103826
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103826

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