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Version: 17.06d (Release date: 2017-06-26)
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Smac Mimetic GDC-0917 (Code C103825)

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Terms & Properties

Preferred Name: Smac Mimetic GDC-0917

Definition: An orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0917 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.

Label: Smac Mimetic GDC-0917

NCI Thesaurus Code: C103825 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433733  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GDC-0917
IAP Antagonist GDC-0917
SMAC/DIABLO Mimetic GDC-0917
Smac Mimetic GDC-0917

External Source Codes: 
PDQ Closed Trial Search ID 688091
PDQ Open Trial Search ID 688091 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433733

Other Properties:
     Name Value (qualifiers indented underneath)
code C103825
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103825

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