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Version: 17.06d (Release date: 2017-06-26)
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Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet (Code C103824)

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Terms & Properties

Preferred Name: Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet

Definition: A prolonged-release tablet formulation composed of the hydrochloride salt form of the opioid receptor agonist oxycodone and the hydrochloride salt form of the opioid receptor antagonist naloxone which may produce analgesia while relieving opioid-mediated gastrointestinal (GI) side effects. Upon oral administration, oxycodone binds to opioid receptors, thereby mimicking the effects of endogenous opiates to provide analgesia. As naloxone is very poorly absorbed, this agent binds locally to opiate receptors in the GI tract, thereby preventing oxycodone from binding to these receptors. This relieves the opioid-related side effects on the GI tract, including opioid-induced constipation.

Label: Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet

NCI Thesaurus Code: C103824 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3180499  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet

External Source Codes: 
PDQ Closed Trial Search ID 742626
PDQ Open Trial Search ID 742626 (check for NCI PDQ open clinical trial info)
UMLS CUI C3180499

Other Properties:
     Name Value (qualifiers indented underneath)
code C103824
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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