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Version: 17.06d (Release date: 2017-06-26)
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XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410 (Code C103823)

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Terms & Properties

Preferred Name: XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410

Definition: A cancer vaccine containing immunogenic, HLA-A2-specific epitopes derived from X-box-binding protein 1-unspliced (XBP1-US), XBP1-spliced (SP), syndecan-1 (CD138), and CS1 (CD2 subset 1, CRACC, SLAMF7, CD319) with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, XBP1-US/XBP1-SP/CD138/CS1 multipeptide vaccine PVX-410 may stimulate the immune system to induce a cytotoxic T-lymphocyte response against the four myeloma-specific antigens. The tumor associated antigens (TAAs) XBP1-US, XBP1-SP, CD138 and CS1, are overexpressed on the surface of multiple myeloma (MM) cells.

Display Name: XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410

Label: XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410

NCI Thesaurus Code: C103823 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438306  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PVX-410
XBP1-US/XBP1-SP/CD138/CS1 Multipeptide Vaccine PVX-410

External Source Codes: 
PDQ Closed Trial Search ID 742602
PDQ Open Trial Search ID 742602 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438306

Other Properties:
     Name Value (qualifiers indented underneath)
code C103823
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103823

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