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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 11 Erlotinib Hydrochloride (Code C103819)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carbon C 11 Erlotinib Hydrochloride

Definition: The hydrochloride salt form of the quinazoline derivative erlotinib labeled with the positron-emitting isotope carbon C 11, with potential use in imaging. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Following exposure to this agent, EGFR expression status can be determined and EGFR overexpressing tumor cells can be visualized using positron emission tomography (PET) imaging. This may be useful in determining the tumor cell response to a particular EGFR kinase inhibitor in individual patients. EGFR, a receptor tyrosine kinase, is overexpressed in numerous cancer cell types, and plays a significant role in tumor cell progression.

Display Name: Carbon C 11 Erlotinib Hydrochloride

Label: Carbon C 11 Erlotinib Hydrochloride

NCI Thesaurus Code: C103819 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438302  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
C11-Erlotinib Hydrochloride
Carbon C 11 Erlotinib Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 742529
PDQ Open Trial Search ID 742529 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438302

Other Properties:
     Name Value (qualifiers indented underneath)
code C103819
Contributing_Source CTRP
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103819

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