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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 d-FMAU (Code C103278)

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Terms & Properties

Preferred Name: Fluorine F 18 d-FMAU

Definition: A radioconjugate comprised of the synthetic pyrimidine analogue 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)thymine (d-FMAU) labeled with the radioisotope fluorine F 18 (18F-d-FMAU), that can potentially be used as an imaging agent upon positron emission tomography (PET). Upon administration, fluorine F 18 FMAU is distributed and taken up by cells based on the rate of the cell's DNA synthesis. Upon PET imaging, cell proliferation in tumors can be assessed as tumor cells have a higher rate of DNA synthesis than normal, healthy cells. This agent is not catabolized and has a long half-life compared to the radioconjugate carbon C 11 thymidine.

Display Name: Fluorine F 18 d-FMAU

Label: Fluorine F 18 d-FMAU

NCI Thesaurus Code: C103278 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL438129  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2'-Deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl)thymine
2'-Deoxy-2'-[18F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil
Fluorine F 18 d-FMAU

External Source Codes: 
PDQ Closed Trial Search ID 741648
PDQ Open Trial Search ID 741648 (check for NCI PDQ open clinical trial info)
NCI META CUI CL438129

Other Properties:
     Name Value (qualifiers indented underneath)
code C103278
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103278

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