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Version: 17.12d (Release date: 2017-12-26)
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Erdafitinib (Code C103273)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Erdafitinib

Definition: An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, erdafitinib binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.

Display Name: Erdafitinib

Label: Erdafitinib

NCI Thesaurus Code: C103273 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3641169  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-(3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl)-
Erdafitinib
ERDAFITINIB
JNJ-42756493

External Source Codes: 
CAS Registry Number 1346242-81-6 (see NLM ChemIDplus info)
FDA UNII Code 890E37NHMV
PDQ Closed Trial Search ID 741845
PDQ Open Trial Search ID 741845 (check for NCI PDQ open clinical trial info)
UMLS CUI C3641169

Other Properties:
     Name Value (qualifiers indented underneath)
code C103273
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C103273

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