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Version: 17.06d (Release date: 2017-06-26)
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pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 (Code C103273)

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Terms & Properties

Preferred Name: pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493

Definition: An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.

Display Name: pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493

Label: pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493

NCI Thesaurus Code: C103273 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3641169  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
JNJ-42756493
pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493

External Source Codes: 
PDQ Closed Trial Search ID 741845
PDQ Open Trial Search ID 741845 (check for NCI PDQ open clinical trial info)
UMLS CUI C3641169

Other Properties:
     Name Value (qualifiers indented underneath)
code C103273
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103273

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