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Version: 17.06d (Release date: 2017-06-26)
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Nitroglycerin Transdermal Patch (Code C103272)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nitroglycerin Transdermal Patch

Definition: A sustained release transdermal patch containing the organic nitrate nitroglycerin, with vasodilator and potential immunomodulating activities. Upon application to the skin, nitroglycerin is continuously released from the patch and absorbed. In turn, nitroglycerin is converted into nitric oxide (NO), which activates guanylyl cyclase, increasing cyclic guanosine monophosphate concentration thus resulting in smooth muscle relaxation. In addition, activation of NO-mediated signaling pathways may inhibit hypoxia-induced tumor cell invasiveness, chemoresistance, evasion of immune cell recognition and cancer cell progression. Particularly, reactivation of NO-mediated signaling appears to inhibit the increased tumor cell shedding of the major histocompatibility complex class I chain-related (MIC) molecules MICA and MICB as is seen in hypoxic tumor environments; MIC molecules play key roles in tumor cell immune surveillance through their interaction with the C-type lectin-like NKG2D receptor on natural killer, lymphokine-activated killer and effector T cells.

Label: Nitroglycerin Transdermal Patch

NCI Thesaurus Code: C103272 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0699222  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Glyceryl Trinitrate Transdermal Patch
GTN Transdermal Patch
Minitran
Nitroglycerin Transdermal Patch

External Source Codes: 
PDQ Closed Trial Search ID 741836
PDQ Open Trial Search ID 741836 (check for NCI PDQ open clinical trial info)
UMLS CUI C0699222

Other Properties:
     Name Value (qualifiers indented underneath)
code C103272
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103272

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