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Version: 17.06d (Release date: 2017-06-26)
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Phellodendron amurense Bark Extract (Code C103230)

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Terms & Properties

Preferred Name: Phellodendron amurense Bark Extract

Definition: A proprietary formulation consisting of a Phellodendron amurense (Amur cork tree) bark extract, often used in traditional Chinese medicine, with anti-inflammatory, anti-oxidant and potential chemopreventive and antineoplastic activities. Phellodendron amurense bark extract contains certain isoquinoline alkaloids, flavone glycosides and phenolic compounds. Upon administration of Phellodendron amurense bark extract, the various phytochemicals in this formulation modulate multiple signal transduction pathways. This agent appears to block the activation of the transcription factor cAMP response binding protein (CREB) and inhibits Akt signaling, thereby inhibiting tumor cell growth and inducing apoptosis in Akt- and CREB-overexpressing cancer cells. In addition, this agent inhibits cyclooxygenase type 2 (COX-2), nuclear factor kappa b (NF-kB) and tumor necrosis factor alpha (TNF-a)-mediated signaling; COX-2, NF-kB and TNF-a are upregulated in certain types of cancer and during inflammation.

Display Name: Phellodendron amurense Bark Extract

Label: Phellodendron amurense Bark Extract

NCI Thesaurus Code: C103230 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3256251  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Phellodendron amurense Bark Extract

External Source Codes: 
PDQ Closed Trial Search ID 741824
PDQ Open Trial Search ID 741824 (check for NCI PDQ open clinical trial info)
UMLS CUI C3256251

Other Properties:
     Name Value (qualifiers indented underneath)
code C103230
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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