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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 4-L-fluoroglutamine (2S,4R) (Code C103196)

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Terms & Properties

Preferred Name: Fluorine F 18 4-L-fluoroglutamine (2S,4R)

Definition: A radioconjugate and glutamine analog consisting of the fluorine F 18 labeled 2S, 4R stereoisomer of 4-fluoroglutamine with potential use as a metabolic tracer for tumor imaging. Upon intravenous administration, fluorine F 18 4-L-fluoroglutamine (2S,4R) is preferentially taken up by cancer cells, possibly driven by c-Myc upregulation. Upon positron emission tomography (PET), cancer cells can be imaged. Tumor cells use the amino acid glutamine for nutritional purposes necessary for energy production and growth; as tumor cells proliferate more rapidly than normal healthy cells, glutamine uptake is higher in certain cancer cells.

Display Name: Fluorine F 18 4-L-fluoroglutamine (2S,4R)

Label: Fluorine F 18 4-L-fluoroglutamine (2S,4R)

NCI Thesaurus Code: C103196 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437435  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F Fluoroglutamine
[18F] 4-L-fluoroglutamine (2S,4R)
Fluorine F 18 4-L-fluoroglutamine (2S,4R)

External Source Codes: 
PDQ Closed Trial Search ID 741122
PDQ Open Trial Search ID 741122 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437435

Other Properties:
     Name Value (qualifiers indented underneath)
code C103196
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103196

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