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Version: 17.06d (Release date: 2017-06-26)
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PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94 (Code C103195)

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Terms & Properties

Preferred Name: PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94

Definition: A proprietary 44-nucleotide L-stereoisomer RNA oligonucleotide conjugated to a 40 kDa polyethylene glycol (PEG) that targets hepcidin with potential anti-anemic activity. Upon intravenous or subcutaneous administration, PEG-linked L-RNA oligonucleotide hepcidin targeting agent NOX-H94 binds to hepcidin and prevents it from binding to the iron channel ferroportin, located on the basolateral surface of gastrointestinal enterocytes and the plasma membrane of macrophages. This prevents hepcidin-induced internalization and degradation of ferroportin, thus decreasing macrophage iron retention. In turn, binding of NOX-H94 to hepcidin normalizes plasma iron levels and increases erythropoiesis. This may inhibit anemia caused by inflammation. Hepcidin, a peptide hormone that plays a key role in the homeostasis of systemic iron, is upregulated during acute and chronic inflammation in response to cytokines. The unique mirror-image configuration of this agent renders it resistant to hydrolysis and shows a low antigenicity profile. Pegylation increases the half-life of this agent.

Label: PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94

NCI Thesaurus Code: C103195 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3641123  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NOX-H94
PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94

External Source Codes: 
PDQ Closed Trial Search ID 740819
PDQ Open Trial Search ID 740819 (check for NCI PDQ open clinical trial info)
UMLS CUI C3641123

Other Properties:
     Name Value (qualifiers indented underneath)
code C103195
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103195

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