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Version: 17.12d (Release date: 2017-12-26)
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Modified Citrus Pectin Supplement (Code C103178)

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Terms & Properties

Preferred Name: Modified Citrus Pectin Supplement

Definition: A dietary supplement containing the modified citrus pectin (MCP) derived from the soluble fiber of citrus fruit peels and a galectin-3 inhibitor with potential antioxidant, hypocholesterolemic, immunostimulatory, metal chelating, and anti-metastatic activities. MCP is a low molecular weight version of pectin composed of short, slightly-branched carbohydrate chains and is modified for enhanced absorbability. The bioactive fragments, most likely the galactan-containing portion, of pectin binds to galectin-3, a carbohydrate-binding protein involved in imflammation, heart disease and is upregulated on the surface of certain types of tumor cells. Binding of MCP may result in the suppression of cancer cell aggregation, adhesion, proliferation and metastasis. In addition, MCP decreases prostate specific antigen (PSA) levels and may remove heavy metals. Also, unsaturated oligogalacturonic acids in MCP may stimulate the immune system through the activation of natural killer cells, cytotoxic T-cells, and B-cells.

Label: Modified Citrus Pectin Supplement

NCI Thesaurus Code: C103178 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437425  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Modified Citrus Pectin Supplement

External Source Codes: 
PDQ Closed Trial Search ID 740207
PDQ Open Trial Search ID 740207 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C103178
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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