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Version: 17.06d (Release date: 2017-06-26)
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Venetoclax (Code C103147)

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Terms & Properties

Preferred Name: Venetoclax

Definition: An orally bioavailable, selective small molecule inhibitor of the anti-apoptotic protein Bcl-2, with potential antineoplastic activity. Venetoclax mimics BH3-only proteins, the native ligands of Bcl-2 and apoptosis activators, by binding to the hydrophobic groove of Bcl-2 proteins thereby repressing Bcl-2 activity and restoring apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in some cancers and plays an important role in the regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival. Compared to the Bcl-2 inhibitor navitoclax, this agent does not inhibit bcl-XL and does not cause bcl-XL-mediated thrombocytopenia.

Display Name: Venetoclax

Label: Venetoclax

NCI Thesaurus Code: C103147 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3659811  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(4-((2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide
ABT-0199
ABT-199
ABT199
GDC-0199
RG7601
Venclexta
Venetoclax
VENETOCLAX

External Source Codes: 
CAS Registry Number 1257044-40-8 (see NLM ChemIDplus info)
FDA UNII Code N54AIC43PW
PDQ Closed Trial Search ID 698675
PDQ Open Trial Search ID 698675 (check for NCI PDQ open clinical trial info)
UMLS CUI C3659811

Other Properties:
     Name Value (qualifiers indented underneath)
code C103147
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103147

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