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Version: 17.06d (Release date: 2017-06-26)
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PBN Derivative OKN-007 (Code C102983)

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Terms & Properties

Preferred Name: PBN Derivative OKN-007

Definition: A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown, this agent appears to inhibit cancer cell proliferation and migration. This agent appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase that is overexpressed in the extracellular matrix of cancer cells and catalyzes the removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may induce changes in tumor metabolism and scavenge free radicals.

Display Name: PBN Derivative OKN-007

Label: PBN Derivative OKN-007

NCI Thesaurus Code: C102983 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2974636  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,4-Disulfonyl PBN
PBN Derivative OKN-007

External Source Codes: 
CAS Registry Number 168021-79-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 739669
PDQ Open Trial Search ID 739669 (check for NCI PDQ open clinical trial info)
UMLS CUI C2974636

Other Properties:
     Name Value (qualifiers indented underneath)
code C102983
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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