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Version: 17.06d (Release date: 2017-06-26)
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Src/Abl Kinase Inhibitor AZD0424 (Code C102976)

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Terms & Properties

Preferred Name: Src/Abl Kinase Inhibitor AZD0424

Definition: An orally bioavailable small molecule tyrosine kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Upon oral administration, AZD0424 selectively inhibits both Src and Abl kinase activity which may result in the inhibition of tumor growth in susceptible tumor cells. Src and Abl kinases are upregulated in certain tumor cells and play important roles in tumor cell proliferation and metastasis.

Label: Src/Abl Kinase Inhibitor AZD0424

NCI Thesaurus Code: C102976 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437215  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD0424
Src/Abl Kinase Inhibitor AZD0424

External Source Codes: 
PDQ Closed Trial Search ID 739328
PDQ Open Trial Search ID 739328 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437215

Other Properties:
     Name Value (qualifiers indented underneath)
code C102976
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102976

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