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Version: 17.12d (Release date: 2017-12-26)
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Buthionine Sulfoximine (Code C1029)

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Terms & Properties

Preferred Name: Buthionine Sulfoximine

Definition: A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04)

NCI-GLOSS Definition: A drug that may help prevent resistance to some anticancer drugs.

Display Name: Buthionine Sulfoximine

Label: Buthionine Sulfoximine

NCI Thesaurus Code: C1029 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0054252  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Amino-4-(S-butylsulfonimidoyl) Butanoic Acid
Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Buthionine Sulfoximine
buthionine sulfoximine
Buthionine Sulphoximine
L-Buthionine sulfoximine
L-Buthionine Sulfoximine
S-(n-Butyl)homocysteine Sulfoximine

External Source Codes: 
CAS Registry Number 83730-53-4 (see NLM ChemIDplus info)
NSC Code 326231 (see NCI DTP info)
PDQ Closed Trial Search ID 39123
PDQ Open Trial Search ID 39123 (check for NCI PDQ open clinical trial info)
UMLS CUI C0054252

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H18N2O3S
code C1029
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Buthionine_Sulfoximine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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