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Version: 17.06d (Release date: 2017-06-26)
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Thioureidobutyronitrile (Code C102881)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thioureidobutyronitrile

Definition: A water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells.

Display Name: Thioureidobutyronitrile

Label: Thioureidobutyronitrile

NCI Thesaurus Code: C102881 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437184  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Kevetrin
Thioureidobutyronitrile

External Source Codes: 
PDQ Closed Trial Search ID 739050
PDQ Open Trial Search ID 739050 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437184

Other Properties:
     Name Value (qualifiers indented underneath)
code C102881
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102881

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