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Version: 17.06d (Release date: 2017-06-26)
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BTK Inhibitor ONO-4059 (Code C102876)

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Terms & Properties

Preferred Name: BTK Inhibitor ONO-4059

Definition: An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Display Name: BTK Inhibitor ONO-4059

Label: BTK Inhibitor ONO-4059

NCI Thesaurus Code: C102876 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437179  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bruton's Tyrosine Kinase Inhibitor ONO-4059
BTK Inhibitor ONO-4059
ONO-4059

External Source Codes: 
PDQ Closed Trial Search ID 738477
PDQ Open Trial Search ID 738477 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437179

Other Properties:
     Name Value (qualifiers indented underneath)
code C102876
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102876

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