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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Nanoparticle-encapsulated Doxorubicin Hydrochloride (Code C102875)

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Terms & Properties

Preferred Name: Nanoparticle-encapsulated Doxorubicin Hydrochloride

Definition: A formulation of nanoparticles encapsulating the hydrochloride salt form of the anthracycline antibiotic doxorubicin, with potential antitumor activity. Upon intravenous administration, doxorubicin intercalates DNA, interferes with the activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. Delivery of doxorubicin in nanoparticles may improve drug penetration into tumors and may circumvent the tumor cells multidrug resistance mechanisms and may therefore be effective in chemoresistant tumor cells.

Label: Nanoparticle-encapsulated Doxorubicin Hydrochloride

NCI Thesaurus Code: C102875 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437178  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Doxorubicin Transdrug
Nanoparticle-encapsulated Doxorubicin Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 738259
PDQ Open Trial Search ID 738259 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102875
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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