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Version: 17.06d (Release date: 2017-06-26)
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Diammonium Glycyrrhizinate (Code C102865)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Diammonium Glycyrrhizinate

Definition: The diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase.

Label: Diammonium Glycyrrhizinate

NCI Thesaurus Code: C102865 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1956193  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18beta-Glycyrrhizic Acid Diammoniumsalt
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-Glucopyranuronosyl-, Diammonium Salt (9CI)
Diammonium Glycyrrhizinate

External Source Codes: 
CAS Registry Number 79165-06-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 737610
PDQ Open Trial Search ID 737610 (check for NCI PDQ open clinical trial info)
UMLS CUI C1956193

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C42H62O16.2H3N
code C102865
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102865

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