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Version: 17.06d (Release date: 2017-06-26)
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Benegrastim (Code C102854)

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Terms & Properties

Preferred Name: Benegrastim

Definition: A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Benegrastim binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.

Display Name: Benegrastim

Label: Benegrastim

NCI Thesaurus Code: C102854 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437135  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Dimeric G-CSF Fusion Protein F627
Rh G-CSF Fc Fusion Protein F-627

External Source Codes: 
PDQ Closed Trial Search ID 737722
PDQ Open Trial Search ID 737722 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102854
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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