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Version: 17.06d (Release date: 2017-06-26)
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Fruquintinib (Code C102852)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fruquintinib

Definition: An orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types.

Label: Fruquintinib

NCI Thesaurus Code: C102852 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640967  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fruquintinib
HMPL-013
VEGFR-1/2/3 Inhibitor HMPL-013

External Source Codes: 
PDQ Closed Trial Search ID 737616
PDQ Open Trial Search ID 737616 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640967

Other Properties:
     Name Value (qualifiers indented underneath)
code C102852
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102852

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