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Version: 17.06d (Release date: 2017-06-26)
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Ulinastatin (Code C102851)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ulinastatin

Definition: A multivalent Kunitz-type serine protease inhibitor derived from human urine, with potential protective, anti-fibrinolytic and anticoagulant activities. Upon administration, ulinastatin (or urinary trypsinogen inhibitor) inhibits the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. In addition, ulinastatin inhibits the excessive release of proinflammatory mediators, such as tumor necrosis factor-alpha, interleukin-6 and -8, and chemokines. Altogether, this agent may improve the microcirculation, perfusion and function of tissues and may protect organ injury.

Label: Ulinastatin

NCI Thesaurus Code: C102851 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0077906  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ulinastatin
Urinary Trypsin Inhibitor
UTI

External Source Codes: 
CAS Registry Number 80449-32-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 737612
PDQ Open Trial Search ID 737612 (check for NCI PDQ open clinical trial info)
UMLS CUI C0077906

Other Properties:
     Name Value (qualifiers indented underneath)
code C102851
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102851

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