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Version: 17.06d (Release date: 2017-06-26)
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Naphthalimide Analogue UNBS5162 (Code C102850)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Naphthalimide Analogue UNBS5162

Definition: An amonafide (naphthalimide) derivative and pan-antagonist of chemokine ligand (CXCL) expression, with potential anti-angiogenic activity. Although UNBS5162 is a derivative of amonafide, this agent appears to have a different profile to that of amonafide and its exact mechanism of action remains to be fully elucidated. This agent seems to decrease the expression of various proangiogenic CXCL chemokines in vitro and may have synergistic effects with radiotherapy or chemotherapy. CXCLs are small cytokines in the CXC chemokine family that are overexpressed in certain cancers; CXCL-mediated signaling plays a key role in angiogenesis and tumor progression.

Display Name: Naphthalimide Analogue UNBS5162

Label: Naphthalimide Analogue UNBS5162

NCI Thesaurus Code: C102850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2603824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-(2-(Dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea
Naphthalimide Analogue UNBS5162
UNBS5162

External Source Codes: 
CAS Registry Number 956590-23-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 737303
PDQ Open Trial Search ID 737303 (check for NCI PDQ open clinical trial info)
UMLS CUI C2603824

Other Properties:
     Name Value (qualifiers indented underneath)
code C102850
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102850

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