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Version: 17.06d (Release date: 2017-06-26)
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Inducible CD4+CD25+ Regulatory T Cells (Code C102789)

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Terms & Properties

Preferred Name: Inducible CD4+CD25+ Regulatory T Cells

Definition: Inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants.

Display Name: Inducible CD4+CD25+ Regulatory T Cells

Label: Inducible CD4+CD25+ Regulatory T Cells

NCI Thesaurus Code: C102789 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437026  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Inducible CD4+CD25+ Regulatory T Cells
iTregs

External Source Codes: 
PDQ Closed Trial Search ID 737145
PDQ Open Trial Search ID 737145 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437026

Other Properties:
     Name Value (qualifiers indented underneath)
code C102789
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102789

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