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Version: 17.06d (Release date: 2017-06-26)
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Deuterated Phenanthrene (Code C102788)

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Terms & Properties

Preferred Name: Deuterated Phenanthrene

Definition: A noncarcinogenic and structural analogue of polycyclic aromatic hydrocarbon (PAH), phenanthrene labeled with deuterium ([D10]Phe) with potential use in assessing an individual's capacity for PAH metabolism by the diol epoxide pathway. Upon oral or inhalation administration, [D10]Phe is metabolized into the tetraol end product ([D10]PheT) via the diol epoxide pathway, and can be quantified in urine. [D10]PheT can be used as a biomarker to assess PAHs metabolic activation and may therefore determine an individual's susceptibility to carcinogenicity upon PAH exposure.

Display Name: Deuterated Phenanthrene

Label: Deuterated Phenanthrene

NCI Thesaurus Code: C102788 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437025  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[D10] phenanthrene
Deuterated Phenanthrene

External Source Codes: 
PDQ Closed Trial Search ID 736819
PDQ Open Trial Search ID 736819 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102788
Contributing_Source CTRP
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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