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Version: 16.10e (Release date: 2016-10-31)
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HPV E6/E7 DNA Vaccine GX-188E (Code C102787)

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Terms & Properties

Preferred Name: HPV E6/E7 DNA Vaccine GX-188E

Definition: A therapeutic DNA vaccine encoding the E6/E7 fusion protein of human papillomavirus (HPV) subtypes 16 and 18, plus the immune-enhancer, Fms-like tyrosine kinase-3 ligand (FLT3L), with potential immunostimulating and antineoplastic activities. DNA vaccine GX-188E is administered using a proprietary delivery system that electroporates the vaccine into cervical cells. Expression of the E6/E7 fusion product may elicit a cytotoxic T-lymphocyte (CTL) response against cervical cancer cells expressing E6 and E7 oncoproteins, resulting in tumor cell lysis. FLT3L is a ligand for the FLT3 tyrosine kinase receptor, which upon activation stimulates the proliferation of hematopoietic progenitor cells. HPV type 16 and 18 are the most common HPV types involved in cervical carcinogenesis.

Label: HPV E6/E7 DNA Vaccine GX-188E

NCI Thesaurus Code: C102787 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437024  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GX-188E
HPV E6/E7 DNA Vaccine GX-188E

External Source Codes: 
PDQ Closed Trial Search ID 736688
PDQ Open Trial Search ID 736688 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437024

Other Properties:
Name Value (qualifiers indented underneath)
code C102787
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102787

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