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Version: 16.10e (Release date: 2016-10-31)
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Pan-Selectin Antagonist GMI-1070 (Code C102786)

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Terms & Properties

Preferred Name: Pan-Selectin Antagonist GMI-1070

Definition: A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.

Display Name: Pan-Selectin Antagonist GMI-1070

Label: Pan-Selectin Antagonist GMI-1070

NCI Thesaurus Code: C102786 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2973594  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GMI-1070
Pan-Selectin Antagonist GMI-1070

External Source Codes: 
PDQ Closed Trial Search ID 736621
PDQ Open Trial Search ID 736621 (check for NCI PDQ open clinical trial info)
UMLS CUI C2973594

Other Properties:
Name Value (qualifiers indented underneath)
code C102786
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102786

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