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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650 (Code C102785)

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Terms & Properties

Preferred Name: Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650

Definition: A radioimmunoconjugate composed of the F(ab')2 fragment of human monoclonal antibody PGN650 against phosphatidylserine (PS) labeled with the radioisotope iodine I 124, with potential imaging activity upon positron-emission tomography (PET). Upon administration, the MoAb moiety of PGN650 binds to exposed PS on tumor cells, thereby allowing for the visualization of tumors upon PET. This may facilitate the assessment of the effectiveness of antitumor agents. The phospholipid PS is normally located on the inner leaflet of the plasma membrane of healthy cells but is flipped to the outer leaflet in the endothelial lining of the tumor vasculature and other tumor cells in response to chemo- or radio- treatments in addition to oxidative stress.

Label: Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650

NCI Thesaurus Code: C102785 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
I-124 Anti-PS MoAb PNG650
I-124 PGN650
Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650

External Source Codes: 
PDQ Closed Trial Search ID 736553
PDQ Open Trial Search ID 736553 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102785
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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