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Version: 17.06d (Release date: 2017-06-26)
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CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes (Code C102758)

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Terms & Properties

Preferred Name: CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes

Definition: Autologous T-lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing autologous T-lymphocytes direct the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19 and the inclusion of this signaling domain may increase the antitumor activity compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3-zeta (or CD247) is a transmembrane signaling adaptor polypeptide that regulates the assembly of complete TCR complexes and their expression on the cell surface.

Display Name: CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes

Label: CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes

NCI Thesaurus Code: C102758 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437013  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CART-19
CART19
CD19CAR-CD3zeta-4-1BB-expressing Autologous T-lymphocytes
CTL019
CTL019 T-cells

External Source Codes: 
PDQ Closed Trial Search ID 736184
PDQ Open Trial Search ID 736184 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437013

Other Properties:
     Name Value (qualifiers indented underneath)
code C102758
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102758

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