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Version: 17.06d (Release date: 2017-06-26)
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Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9 (Code C102757)

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Terms & Properties

Preferred Name: Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9

Definition: Allodepleted haploidentical T-lymphocytes transduced with the Gal-V pseudotyped retrovirus vector encoding SFG.iCasp9-2A-deltaCD19, with potential immune reconstitution property. SFG.iCasp9-2A-deltaCD19 contains the suicide gene inducible caspase 9 (iCasp9) linked with a 2A-like cleavable peptide to the selectable marker, truncated human CD19 (deltaCD19). iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9 using a short linker (SGGGS). Donor T cell therapy may help control transplant-related viral infections following allogeneic hematopoietic stem cell transplantation. However, even the addition of allodepleted donor T cells can lead to graft-versus-host disease (GVHD). In the event that GVHD begins to develop, the chemical homodimerizer AP1903 can be administered, which binds to the FKBP12-F36V domain activating caspase 9. This results in the death of T cells causing GVHD while sparing the virus reactive T-cells.

Display Name: Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9

Label: Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9

NCI Thesaurus Code: C102757 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437012  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9
iCasp9 Allogeneic T Cells

External Source Codes: 
PDQ Closed Trial Search ID 736015
PDQ Open Trial Search ID 736015 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437012

Other Properties:
     Name Value (qualifiers indented underneath)
code C102757
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102757

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