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Version: 17.06d (Release date: 2017-06-26)
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Zirconium Zr 89-labeled Anti-PlGF Monoclonal Antibody RO5323441 (Code C102750)

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Terms & Properties

Preferred Name: Zirconium Zr 89-labeled Anti-PlGF Monoclonal Antibody RO5323441

Definition: A radioimmunoconjugate comprised of the humanized IgG1 monoclonal antibody directed against placental growth factor (PlGF) and labeled with zirconium Zr 89 (Zr 89), with potential radiotracer activity upon positron emission tomography (PET) imaging. The monoclonal antibody moiety of RO5323441 binds to both PlGF-1 and -2, thereby preventing the binding of PlGF-1 and -2 to the vascular endothelial growth factor receptor-1 (VEGFR-1) and the subsequent activation of VEGFR-1. The radioisotope moiety of RO5323441 may be detected using PET, thereby allowing for visualization of the antibody's distribution and PlGF expression. PlGF, a member of the VEGF sub-family and a key molecule in angiogenesis and vasculogenesis, is upregulated in many cancers.

Label: Zirconium Zr 89-labeled Anti-PlGF Monoclonal Antibody RO5323441

NCI Thesaurus Code: C102750 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640931  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
89Zr-RO5323441
Zirconium Zr 89-labeled Anti-PlGF Monoclonal Antibody RO5323441

External Source Codes: 
PDQ Closed Trial Search ID 735817
PDQ Open Trial Search ID 735817 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640931

Other Properties:
     Name Value (qualifiers indented underneath)
code C102750
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102750

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