skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Heparan Sulfate Glycosaminoglycan Mimetic M402 (Code C102749)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Heparan Sulfate Glycosaminoglycan Mimetic M402

Definition: A low molecular weight heparin derivative and heparan sulfate proteoglycan (HSPG) mimetic with no or minimal anticoagulant activity and potential antineoplastic activities. Upon administration, M402 mimics HSPGs by binding to and inhibiting various heparin-binding growth factors, chemokines, and cytokines such as VEGF, HGF, FGF2, SDF-1a, heparanase and P-selectin all of which are essential for tumor angiogenesis and metastasis to occur. This inhibits heparin binding growth factor-mediated signaling and disrupts tumor-stromal interactions eventually leading to an inhibition of angiogenesis and tumor cell progression. In addition, M402 may enhance the cytotoxic effect of other chemotherapeutic agents.

Display Name: Heparan Sulfate Glycosaminoglycan Mimetic M402

Label: Heparan Sulfate Glycosaminoglycan Mimetic M402

NCI Thesaurus Code: C102749 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437006  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Heparan Sulfate Glycosaminoglycan Mimetic M402
HSGAG Mimetic M402
M402

External Source Codes: 
PDQ Closed Trial Search ID 735811
PDQ Open Trial Search ID 735811 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437006

Other Properties:
     Name Value (qualifiers indented underneath)
code C102749
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102749

Mainbox Bottom