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Version: 17.06d (Release date: 2017-06-26)
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PARP 1/2 Inhibitor E7449 (Code C102746)

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Terms & Properties

Preferred Name: PARP 1/2 Inhibitor E7449

Definition: An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA.

Label: PARP 1/2 Inhibitor E7449

NCI Thesaurus Code: C102746 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437003  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E7449
PARP 1/2 Inhibitor E7449

External Source Codes: 
PDQ Closed Trial Search ID 735791
PDQ Open Trial Search ID 735791 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437003

Other Properties:
     Name Value (qualifiers indented underneath)
code C102746
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102746

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