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Version: 17.06d (Release date: 2017-06-26)
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Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation (Code C102745)

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Terms & Properties

Preferred Name: Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation

Definition: An extended release (ER) injectable formulation composed of the hydrochloride salt form of bupivacaine, an amide-type, long-acting local anesthetic, in a resorbable sucrose acetate isobutyrate-based matrix, with analgesic activity. Following administration in or around a specific site, ER bupivacaine is released from the matrix over an extended period of time. Upon release, bupivacaine reversibly binds to specific voltage-gated sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions, membrane destabilization, and depolarization inhibition thus disrupting nerve impulse conduction. This eventually leads to a reversible loss of sensation. This formulation may provide pain relief up to 72 hours.

Display Name: Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation

Label: Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation

NCI Thesaurus Code: C102745 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL437002  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ER Bupivacaine HCl
Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation
SABER-Bupivacaine Hydrochloride
Sustained Release Bupivacaine Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 735755
PDQ Open Trial Search ID 735755 (check for NCI PDQ open clinical trial info)
NCI META CUI CL437002

Other Properties:
     Name Value (qualifiers indented underneath)
code C102745
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102745

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