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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Bryostatin 1 (Code C1026)

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Terms & Properties

Preferred Name: Bryostatin 1

Definition: A macrocyclic lactone isolated from the bryozoan Bugula neritina with antineoplastic activity. Bryostatin 1 binds to and inhibits the cell-signaling enzyme protein kinase C, resulting in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. This agent may act synergistically with other chemotherapeutic agents. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer and certain brain conditions such as Alzheimer disease and stroke. It binds to an enzyme involved in cell growth and it may help anticancer drugs work better. Bryostatin 1 comes from a marine organism. It is a type of protein kinase C modulator.

Display Name: Bryostatin 1

Label: Bryostatin 1

NCI Thesaurus Code: C1026 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0054173  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B705008K112
Bryostatin 1
BRYOSTATIN 1
bryostatin 1
Bryostatin I

External Source Codes: 
CAS Registry Number 83314-01-6 (see NLM ChemIDplus info)
FDA UNII Code 37O2X55Y9E
NSC Code 339555 (see NCI DTP info)
PDQ Closed Trial Search ID 41959
PDQ Open Trial Search ID 41959 (check for NCI PDQ open clinical trial info)
UMLS CUI C0054173

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C47H68O17
code C1026
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Bryostatin-1
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1026

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