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Version: 17.06d (Release date: 2017-06-26)
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Epoetin Zeta (Code C102571)

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Terms & Properties

Preferred Name: Epoetin Zeta

Definition: A recombinant form of the endogenous human cytokine erythropoietin (EPO) with erythropoiesis-stimulating activity. Similar to EPO, epoetin zeta binds to and activates erythropoietin receptors on the surface of committed erythroid progenitors in the bone marrow resulting in their proliferation and differentiation into functional erythrocytes. This may enhance red blood cell counts and hemoglobin levels. Epoetin zeta differs from other epoetins in its glycosylation profile. EPO is a glycosylated polypeptide primarily produced by renal peritubular cells and its synthesis is regulated by a serum oxygenation feedback mechanism.

Label: Epoetin Zeta

NCI Thesaurus Code: C102571 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1997870  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Epoetin Zeta
Retacrit
SB309
Silapo

External Source Codes: 
PDQ Closed Trial Search ID 735936
PDQ Open Trial Search ID 735936 (check for NCI PDQ open clinical trial info)
UMLS CUI C1997870

Other Properties:
     Name Value (qualifiers indented underneath)
code C102571
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102571

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