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Version: 17.06d (Release date: 2017-06-26)
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Recombinant EphB4-HSA Fusion Protein (Code C102569)

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Terms & Properties

Preferred Name: Recombinant EphB4-HSA Fusion Protein

Definition: A recombinant fusion protein composed of the full-length extracellular domain (soluble) of human receptor tyrosine kinase ephrin type-B receptor 4 (sEphB4) and fused, at its C-terminus, to full-length human serum albumin (HSA), with potential antineoplastic and anti-angiogenic activities. sEphB4-HSA functions as a decoy receptor for the membrane-bound ligand Ephrin-B2 (Efnb2) and interferes with the binding of Efnb2 to its native receptors, including EphB4 and EphA3. This may result in a reduction of angiogenesis and a reduction in cell growth of Efnb2 and/or EphB4 over-expressing tumor cells. In addition, this agent also prevents the angiogenic effects of numerous growth factors due to interactions between Efnb2 and EphB4. Efnb2 and EphB4 are overexpressed in a variety of tumor cell types; the bi-directional signaling of Efnb2-EphB4 plays an important role in angiogenesis and tumor cell migration, invasion, and proliferation. Albumin reduces this agent's degradation, improves circulation time and may thus improve efficacy.

Display Name: Recombinant EphB4-HSA Fusion Protein

Label: Recombinant EphB4-HSA Fusion Protein

NCI Thesaurus Code: C102569 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436876  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant EphB4-HSA Fusion Protein
sEphB4-HSA

External Source Codes: 
PDQ Closed Trial Search ID 735271
PDQ Open Trial Search ID 735271 (check for NCI PDQ open clinical trial info)
NCI META CUI CL436876

Other Properties:
     Name Value (qualifiers indented underneath)
code C102569
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102569

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