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Version: 17.06d (Release date: 2017-06-26)
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Docetaxel Lipid Microspheres (Code C102568)

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Terms & Properties

Preferred Name: Docetaxel Lipid Microspheres

Definition: A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile.

Label: Docetaxel Lipid Microspheres

NCI Thesaurus Code: C102568 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436875  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DLE
Docetaxel Lipid Emulsion
Docetaxel Lipid Microspheres
DT-LM

External Source Codes: 
PDQ Closed Trial Search ID 735255
PDQ Open Trial Search ID 735255 (check for NCI PDQ open clinical trial info)
NCI META CUI CL436875

Other Properties:
     Name Value (qualifiers indented underneath)
code C102568
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102568

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