skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Docetaxel Lipid Microspheres (Code C102568)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Docetaxel Lipid Microspheres

Definition: A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile.

Label: Docetaxel Lipid Microspheres

NCI Thesaurus Code: C102568 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436875  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Docetaxel Lipid Emulsion
Docetaxel Lipid Microspheres

External Source Codes: 
PDQ Closed Trial Search ID 735255
PDQ Open Trial Search ID 735255 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102568
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom