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Version: 16.11d (Release date: 2016-11-28)
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Ipafricept (Code C102565)

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Terms & Properties

Preferred Name: Ipafricept

Definition: A proprietary fusion protein comprised of the cysteine-rich domain of frizzled family receptor 8 (Fzd8) fused to the human immunoglobulin Fc domain with potential antineoplastic activity. Upon intravenous administration, ipafricept competes with the membrane-bound Fzd8 receptor for its ligand, Wnt proteins, thereby antagonizing Wnt signaling. This may result in the inhibition of Wnt-driven tumor growth. Fzd8, a member of the Frizzled family of G protein-coupled receptors, is one of the components in the Wnt/beta-catenin signaling pathway that plays key roles in embryogenesis and cancer growth.

Display Name: Ipafricept

Label: Ipafricept

NCI Thesaurus Code: C102565 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436872  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Fusion Protein For Immune Applications (fpia) Comprising Homo Sapiens FZD8 (Frizzled Family Receptor 8, Frizzled-8) Extracellular Domain, Fused With Homo Sapiens Immunoglobulin G1 Fc Fragment
Fzd8-Fc
Ipafricept
IPAFRICEPT
OMP-54F28
OMP 54F28

External Source Codes: 
CAS Registry Number 1391727-24-4 (see NLM ChemIDplus info)
FDA UNII Code 2N71QUE3NL
PDQ Closed Trial Search ID 734935
PDQ Open Trial Search ID 734935 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 17545618 (see PubMed Primary Reference info)
NCI META CUI CL436872

Other Properties:
Name Value (qualifiers indented underneath)
code C102565
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102565

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