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Version: 17.08d (Release date: 2017-08-28)
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Beta-hydroxy-beta-methylbutyrate Supplement (Code C102547)

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Terms & Properties

Preferred Name: Beta-hydroxy-beta-methylbutyrate Supplement

Definition: A nutritional supplement containing the active metabolite of the essential amino acid leucine, with potential anti-catabolic and anabolic activities. Upon oral administration of beta-hydroxy-beta-methylbutyrate (HMB), this leucine metabolite may decrease protein breakdown and increase protein synthesis thereby increasing muscle strength and mass. Although the exact mechanisms remain to be fully elucidated, multiple mechanisms have been proposed: 1) HMB is a precursor of cholesterol synthesis in skeletal muscle cells thereby increasing sarcolemmal integrity; 2) HMB may inhibit the ubiquitin-proteasome proteolytic pathway responsible for the specific degradation of intracellular proteins, thereby preventing muscular proteolysis; and/or 3) HMB may stimulate protein synthesis through a mammalian target of rapamycin (mTOR)-mediated mechanism.

Label: Beta-hydroxy-beta-methylbutyrate Supplement

NCI Thesaurus Code: C102547 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436816  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beta-hydroxy-beta-methylbutyrate Supplement
HMB Supplement

External Source Codes: 
PDQ Closed Trial Search ID 734830
PDQ Open Trial Search ID 734830 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C102547
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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