skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Selinexor (Code C102546)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Selinexor

Definition: An orally available, small molecule inhibitor of CRM1 (chromosome region maintenance 1 protein, exportin 1 or XPO1), with potential antineoplastic activity. Selinexor modifies the essential CRM1-cargo binding residue cysteine-528, thereby irreversibly inactivates CRM1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (TSPs), including p53, p21, BRCA1/2, pRB, FOXO, and other growth regulatory proteins. As a result, this agent, via the approach of selective inhibition of nuclear export (SINE), restores endogenous tumor suppressing processes to selectively eliminate tumor cells while sparing normal cells. CRM1, the major export factor for proteins from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types.

Display Name: Selinexor

Label: Selinexor

NCI Thesaurus Code: C102546 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3640806  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CRM1 Nuclear Export Inhibitor KPT-330
KPT-330
Selective Inhibitor of Nuclear Export KPT-330
Selinexor
SINE KPT-330

External Source Codes: 
PDQ Closed Trial Search ID 734824
PDQ Open Trial Search ID 734824 (check for NCI PDQ open clinical trial info)
UMLS CUI C3640806

Other Properties:
     Name Value (qualifiers indented underneath)
code C102546
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102546

Mainbox Bottom