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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta (Code C102545)

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Terms & Properties

Preferred Name: Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta

Definition: A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene, with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, recombinant VSV expressing IFN-b replicates in the tumor environment specifically, partially due to defective innate antiviral host defense mechanisms in tumor cells, involving type I IFNs, and exerts its cytolytic activity towards the tumor cells. By expressing human IFN-b, an INF-b-mediated antiviral immune response in surrounding normal cells is activated which protects normal cells against virus replication and VSV-mediated cell lysis. However, tumor cells have a defective IFN-b-mediated innate antiviral immune response allowing for VSV to replicate in these cells without interference. In addition, the IFN-b produced by VSV may activate an immune response in surrounding normal cells and may activate T-lymphocytes, dendritic cells and natural killer cells; thus, inducing an anti-tumor immune response against the tumor cells. VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans.

Display Name: Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta

Label: Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta

NCI Thesaurus Code: C102545 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436814  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta
Recombinant VSV-IFN-beta
VSV-hIFN-b

External Source Codes: 
PDQ Closed Trial Search ID 734527
PDQ Open Trial Search ID 734527 (check for NCI PDQ open clinical trial info)
NCI META CUI CL436814

Other Properties:
     Name Value (qualifiers indented underneath)
code C102545
Contributing_Source CTRP
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C102545

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