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Version: 17.06d (Release date: 2017-06-26)
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Bruceantin (Code C1025)

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Terms & Properties

Preferred Name: Bruceantin

Definition: A triterpene quassinoid antineoplastic antibiotic isolated from the plant Brucea antidysenterica. Bruceantin inhibits the peptidyl transferase elongation reaction, resulting in decreased protein and DNA synthesis. Bruceantin also has antiamoebic and antimalarial activity. (NCI04)

Label: Bruceantin

NCI Thesaurus Code: C1025 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0054160  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2H-3, 11c-(Epoxymethano)phenanthro[10,1-bc]pyran, Picras-3-en-21-oic Acid Derivative
[11Beta,12alpha,15beta(E)]-15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxopicras-3-en-21-oic Acid Methyl Ester
Bruceantin
BRUCEANTIN
Picras-3-en-21-oic Acid, 15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11, 12-trihydroxy-2,16-dioxo-, Methyl Ester, (11beta,12alpha,15beta(E))
Picras-3-en-21-oic acid, 15-[(3, 4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2, 16-dioxo-, methyl ester, [11.beta.,12.alpha.,15.beta.(E)]-
Picras-3-en-21-oic acid, 15-[(3, 4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2, 16-dioxo-, methyl ester [11.beta.,12.alpha.,15.beta.(E)]-

External Source Codes: 
CAS Registry Number 41451-75-6 (see NLM ChemIDplus info)
NSC Code 165563 (see NCI DTP info)
PDQ Closed Trial Search ID 39169
PDQ Open Trial Search ID 39169 (check for NCI PDQ open clinical trial info)
UMLS CUI C0054160

Other Properties:
     Name Value (qualifiers indented underneath)
code C1025
Legacy_Concept_Name Bruceantin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1025

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