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Version: 17.06d (Release date: 2017-06-26)
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EphA2-targeting DOPC-encapsulated siRNA (Code C101889)

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Terms & Properties

Preferred Name: EphA2-targeting DOPC-encapsulated siRNA

Definition: A liposomal formulation consisting of short-interfering RNAs (siRNAs) directed against ephrin type-A receptor 2 (EphA2) and encapsulated into 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) neutral liposomes, with potential antineoplastic activity. Upon internalization, EphA2-targeting DOPC-encapsulated siRNA can hybridize to EphA2 DNA and mRNA, thereby interfering with both the transcription and translation of EphA2, and thus inhibiting tumor cell growth. The cell-surface receptor EphA2, a member of the ephrin family of receptor tyrosine kinases (RTKs) involved in mammalian development, is overexpressed by a variety of different cancer cell types and plays an important role in tumor growth.

Display Name: EphA2-targeting DOPC-encapsulated siRNA

Label: EphA2-targeting DOPC-encapsulated siRNA

NCI Thesaurus Code: C101889 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL436272  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EphA2-targeting DOPC-encapsulated siRNA
siRNA-EphA2-DOPC

External Source Codes: 
PDQ Closed Trial Search ID 733792
PDQ Open Trial Search ID 733792 (check for NCI PDQ open clinical trial info)
NCI META CUI CL436272

Other Properties:
     Name Value (qualifiers indented underneath)
code C101889
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101889

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