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Version: 17.08d (Release date: 2017-08-28)
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Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes (Code C101796)

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Terms & Properties

Preferred Name: Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

Definition: A population of allogeneic cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad) with potential immunomodulating and anti-adenoviral activities. Upon immunoprophylactic adoptive cell therapy, infusion of allogeneic Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant or in Ad-infected immunocompromised hosts. These allogeneic Ad-specific CTLs are prepared by multiple rounds of stimulation with donor peripheral blood mononuclear cells and lymphoblastoid cell lines that have been transduced with Ad5f35, a recombinant adenoviral vector carrying no transgene.

Display Name: Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

Label: Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

NCI Thesaurus Code: C101796 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435914  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic Adenovirus-specific CTLs
Allogeneic Adenovirus-specific Cytotoxic T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 733688
PDQ Open Trial Search ID 733688 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C101796
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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