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Version: 17.06d (Release date: 2017-06-26)
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Linoleyl Carbonate-paclitaxel (Code C101792)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Linoleyl Carbonate-paclitaxel

Definition: A formulation of the 6-omega fatty acid derivative 2'-linoleyl carbonate (LOC) conjugated to paclitaxel, a taxane compound extracted from the Pacific yew tree Taxus brevifolia, with potential antineoplastic activity. Paclitaxel binds to and stabilizes tubulin, thereby interfering with the dynamics of microtubule assembly/disassembly and resulting in the inhibition of cell division. LOC enhances the uptake of paclitaxel by tumor cells, thereby concentrating this agent in tumor cells compared to normal cells, and may decrease its toxicity profile; fatty acids serve as energy sources and biochemical precursors for the fast growing tumor cells.

Display Name: Linoleyl Carbonate-paclitaxel

Label: Linoleyl Carbonate-paclitaxel

NCI Thesaurus Code: C101792 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL435910  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Linoleyl Carbonate-paclitaxel
Linoleyl Carbonate-paclitaxel
LOC-paclitaxel

External Source Codes: 
PDQ Closed Trial Search ID 733643
PDQ Open Trial Search ID 733643 (check for NCI PDQ open clinical trial info)
NCI META CUI CL435910

Other Properties:
     Name Value (qualifiers indented underneath)
code C101792
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C101792

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